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40 in 2015 a paper published in the bmj that reanalysed the original case notes argued that in study 329, 41 assessing paroxetine and imipramine against placebo in adolescents with depression, the incidence of suicidal behavior had been under-reported and the efficacy exaggerated for paroxetine.
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Other notable signs and symptoms observed with overdoses involving paroxetine alone or with other substances include mydriasis, convulsions including status epilepticus , ventricular dysrhythmias including torsade de pointes , hypertension, aggressive reactions, syncope, hypotension, stupor, bradycardia, dystonia, rhabdomyolysis, symptoms of hepatic dysfunction including hepatic failure, hepatic necrosis, jaundice, hepatitis, and hepatic steatosis , serotonin syndrome, manic reactions, myoclonus, acute renal failure, and urinary retention.
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The long-term efficacy of paroxetine in treating obsessive compulsive disorder has been examined in three 24-week maintenance studies with relapse prevention design.
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, paroxetine is the most potent ssri with regard to cyp2d6, but it is only 2 3-fold more potent than its metabolite m2 , which is equipotent with fluoxetine and its metabolite, norfluoxetine.
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paroxetine has serious interactions with at least 96 different drugs.